Top 20 Drug Discovery Targets: List, Popularity & Companies

Top 20 Drug Discovery Targets: A Comprehensive List & Companies

This comprehensive list highlights 20 of the most popular targets for drug discovery and design, ranked by their current popularity. Additionally, we provide a list of companies actively working on these targets. Please note that this information may evolve as research progresses.

Popular Targets:

CD47
PD-1 (Programmed cell death protein 1)
EGFR (Epidermal growth factor receptor)
HER2 (Human epidermal growth factor receptor 2)
BTK (Bruton's tyrosine kinase)
PARP (Poly ADP-ribose polymerase)
PI3K (Phosphatidylinositol 3-kinase)
ALK (Anaplastic lymphoma kinase)
JAK2 (Janus kinase 2)
BCR-ABL (Breakpoint cluster region-Abelson tyrosine kinase)
CDK4/6 (Cyclin-dependent kinase 4/6)
VEGFR (Vascular endothelial growth factor receptor)
FGFR (Fibroblast growth factor receptor)
IDH1 (Isocitrate dehydrogenase 1)
KRAS (Kirsten rat sarcoma viral oncogene homolog)
RET (Rearranged during transfection)
ALDH1 (Aldehyde dehydrogenase 1)
HSP90 (Heat shock protein 90)
HDAC (Histone deacetylase)
mTOR (Mechanistic target of rapamycin)

Companies Working on These Targets:

CD47: Trillium Therapeutics, Forty Seven Inc.
PD-1: Bristol Myers Squibb, Merck, Roche
EGFR: AstraZeneca, Boehringer Ingelheim, Pfizer
HER2: Genentech, Pfizer, Novartis
BTK: AbbVie, Johnson & Johnson, BeiGene
PARP: AstraZeneca, GlaxoSmithKline, Pfizer
PI3K: Novartis, Bayer, Gilead Sciences
ALK: Pfizer, Takeda, Roche
JAK2: Incyte Corporation, Novartis, Celgene
BCR-ABL: Novartis, Bristol Myers Squibb, Pfizer
CDK4/6: Pfizer, Novartis, Eli Lilly
VEGFR: Pfizer, Novartis, Bayer
FGFR: Janssen, Incyte Corporation, AstraZeneca
IDH1: Agios Pharmaceuticals, Celgene, Bayer
KRAS: Amgen, Mirati Therapeutics, Boehringer Ingelheim
RET: Blueprint Medicines, Eli Lilly, Bayer
ALDH1: Stemcentrx (AbbVie), OncoMed Pharmaceuticals, Inc.
HSP90: Novartis, Synta Pharmaceuticals, Astex Pharmaceuticals
HDAC: Celgene, Merck, Novartis
mTOR: Novartis, Pfizer, AstraZeneca

Please remember that this list is not exhaustive and additional companies may be involved in research and development focused on these targets.