Carotid Plaque Neovascularization, Thrombus Formation, and Stroke Risk

The development of neovascularization within carotid artery plaques is a critical factor in stroke development. This process, along with the formation of floating thrombi and ulcers due to plaque rupture, forms a dangerous chain reaction. Here's how it unfolds:

1. Neovascularization: New blood vessels form within the plaque, but these vessels are fragile and prone to leakage.
2. Thrombus Formation: The leakage from these fragile vessels contributes to the formation of floating thrombi (blood clots) on the plaque's surface.
3. Plaque Rupture: As the plaque grows and weakens, it can rupture, exposing the underlying tissue and the floating thrombus to the bloodstream.
4. Stroke: When a floating thrombus breaks away from the plaque, it can travel to the brain and block blood flow, leading to a stroke.

Therefore, the detachment of a formed floating thrombus, triggered by the cascade of neovascularization, thrombus formation, and plaque rupture, is a primary cause of strokes. Understanding this sequence of events is crucial for effective stroke prevention and treatment strategies.