Carotid Plaque Neovascularization, Thrombus Formation, and Stroke Risk

The development of neovascularization within carotid artery plaques is a critical factor in stroke risk. This process, along with the subsequent formation of floating thrombi and ulcers resulting from plaque rupture, forms a sequential chain of events. Essentially, neovascularization weakens the plaque structure, making it prone to rupture. This can lead to the formation of floating thrombi (blood clots) within the artery. When these thrombi detach, they can travel to the brain, blocking blood flow and causing a stroke. Therefore, the detachment of these formed floating thrombi serves as the primary cause of stroke in this context.