Carotid Plaque Neovascularization: A Chain Reaction Leading to Stroke

The process of neovascularization within carotid artery plaques is a significant contributor to the development of stroke. This process can be understood as a chain reaction, beginning with the formation of new blood vessels within the plaque. This neovascularization weakens the plaque structure, making it prone to rupture. When a plaque ruptures, it exposes the underlying tissue, triggering the formation of blood clots known as thrombi. These thrombi, particularly the 'floating thrombi' that are loosely attached, can detach from the plaque and travel through the bloodstream. If a floating thrombus reaches the brain and blocks blood flow, it causes a stroke. Therefore, understanding the link between carotid plaque neovascularization, thrombus formation, and subsequent stroke is crucial for effective prevention and treatment strategies.