what is MPL pY593D mutation meaning
The MPL p.Y593D mutation refers to a change in the MPL gene that leads to the substitution of the amino acid tyrosine (Y) with aspartic acid (D) at position 593 in the MPL protein. This mutation has been associated with various blood disorders, including myeloproliferative neoplasms, thrombocytosis, and primary myelofibrosis. It is thought to increase the activity of the MPL protein, resulting in the overproduction of blood cells and the development of these disorders.
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