Use a more scientific expression translate these sentences：Multidrug resistance MDR which is linked to the overexpression of ATP binding cassette ABC transporters like P-glycoprotein P-gp breast cance

Multidrug resistance (MDR), which is associated with the overexpression of ATP binding cassette (ABC) transporters such as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and multidrug resistance-associated proteins (MRPs), presents a significant obstacle to cancer chemotherapy. Notably, several lamellarins demonstrate comparable toxicity to MDR and their corresponding parental cell lines. At non-toxic concentrations, lamellarin I (9) significantly enhances the cytotoxicity of doxorubicin, vinblastine, and daunorubicin in MDR cells, exhibiting a 9- to 16-fold greater potency than verapamil. Moreover, lamellarin I (9) not only elevates the intracellular concentration of rhodamine 123 in P-gp-positive LoVo/Dx cells treated with the dye in a dose-dependent manner, but also increases it to levels observed in sensitive parental cells at 10μM. These results suggest that lamellarin I (9) reverses MDR by directly inhibiting P-gp-mediated drug efflux.