作为生物医学成像中典型的生物标志物胆碱被应用于人类前列腺癌肿瘤成像模型中特别是在PET中应用尤为广泛。然而该方法使用的放射性生物代谢小分子对人体有潜在伤害因此我们设计合成了叠氮胆碱特异性响应的打开型近红外荧光探针CyOH-TPA。翻译成英文

As a typical biomarker in biomedical imaging, acetylcholine has been applied in human prostate cancer tumor imaging models, particularly in PET. However, the use of radioactive small molecular metabolic biomolecules in this method has potential harm to the human body. Therefore, we designed and synthesized an open-type near-infrared fluorescent probe (CyOH-TPA) that responds specifically to azido acetylcholine.