把这段话翻译成英文Marchetti22课题组认为LamD可以诱导人黑色素瘤细胞系HBL和人骨肉瘤SAOS2癌细胞衰老。他们发现LamD在TopI突变的癌细胞中没有诱导衰老的活性因此推测LamD的诱导衰老的通路与TopI有关。另外他们还发现LamD抑制TopI酶导致DNA损伤之后会引发胞内ROS水平的提高会进一步导致细胞的衰老。

The Marchetti[22] team suggests that LamD can induce senescence in human melanoma cell line HBL and human osteosarcoma cancer cell SAOS2. They found that LamD does not induce senescence in cancer cells with TopI mutation, suggesting that the senescence-inducing pathway of LamD is related to TopI. Furthermore, they found that LamD can inhibit TopI enzyme, leading to an increase in intracellular ROS level and further inducing cell senescence.