请把下列语句用不同的英文语句表示出来意思不变：糖基化修饰在调节巨噬细胞极化和分化中发挥作用。巨噬细胞表面许多功能重要的分子是N-糖基化的包括整合素、TNFα受体TNFR、TGFβ受体TGFβR、CD206和CD301。此外细胞表面的唾液酸可能调节巨噬细胞与肿瘤细胞的相互作用。例如TAM通过Siglec-9与癌症细胞中含唾液酸聚糖的唾液酸结合可诱导M1巨噬细胞极性化并促进肿瘤微环境中的炎症反应减少肿

Glycosylation modification plays a role in regulating macrophage polarization and differentiation. Many functionally important molecules on the surface of macrophages are N-glycosylated, including integrins, TNFα receptors (TNFR), TGFβ receptors (TGFβR), CD206, and CD301. Additionally, cell surface sialic acid may regulate the interaction between macrophages and tumor cells. For example, TAMs can induce M1 macrophage polarization and promote inflammation in the tumor microenvironment by binding to sialylated glycosaminoglycans on cancer cells via Siglec-9, thereby reducing tumor growth. [3]

The process of glycosylation modification is involved in regulating the polarization and differentiation of macrophages. Various crucial molecules on the surface of macrophages, such as integrins, TNFα receptors (TNFR), TGFβ receptors (TGFβR), CD206, and CD301, are N-glycosylated. Moreover, the presence of sialic acid on the cell surface may regulate the interaction between macrophages and tumor cells. For instance, TAMs can induce M1 macrophage polarization and promote inflammation in the tumor microenvironment by binding to sialylated glycosaminoglycans on cancer cells via Siglec-9, which leads to reduced tumor growth. [3]

The modification of glycosylation plays a significant role in regulating the polarization and differentiation of macrophages. Many essential molecules on the surface of macrophages, including integrins, TNFα receptors (TNFR), TGFβ receptors (TGFβR), CD206, and CD301, are N-glycosylated. Furthermore, the presence of sialic acid on the cell surface can regulate the interaction between macrophages and tumor cells. For example, TAMs can induce M1 macrophage polarization and promote inflammation in the tumor microenvironment by binding to sialylated glycosaminoglycans on cancer cells via Siglec-9, ultimately resulting in reduced tumor growth. [3]