The SHANK3 gene encodes a scaffolding protein on excitatory synapses which coordinates the response of cells to signals from presynaptic cells by organizing other proteins on the postsynaptic cell mem

Researchers have used gene-editing technology to create macaque monkeys with mutations in the SHANK3 gene that are linked to autism in humans. The team found that the monkeys exhibited behaviours that were similar to those seen in humans with autism spectrum disorders, including reduced social interaction, increased repetitive behaviours, anxiety and sleep disorders. The monkeys also had altered brain structure and connectivity. The study is the first to create monkeys with specific genetic mutations linked to autism, which the researchers said could help them to better understand the condition and develop new treatments. The researchers used CRISPR-Cas9 gene editing technology to create the monkeys, which they said have more complex brains than mice, which are often used in animal studies of autism.