CO3 as a Potential Biomarker for Differentiating HCC and mLC from Healthy Individuals

CO3, especially the oligomannose modified form, appears to have a strong ability to differentiate between healthy individuals and patients with HCC and mLC. Fig.8 demonstrates that both the protein expression and oligomannose-type N-glycosylation of CO3 were increased in patients with HCC and mLC. To classify HCC and mLC patients, Receiver Operating Characteristic (ROC) curves were created for CO3 from the NC, HCC, and mLC groups. The AUC for CO3 protein expression was approximately 0.75, while the AUC for oligomannose modified CO3 was above 0.9. Combining the levels of CO3 protein and oligomannose glycosylation resulted in AUCs of 0.993 and 0.988, respectively.