AURKA通过什么调控kras下游通路并提供doi号

AURKA可以通过调节MAPK/ERK和PI3K/AKT通路来影响KRAS下游信号传导。具体地，AURKA可以促进MAPK/ERK通路的激活，从而增强KRAS下游信号传导的强度和稳定性；同时，AURKA也可以抑制PI3K/AKT通路的活性，从而减弱KRAS下游信号传导的强度。这些调节作用可以影响细胞增殖、凋亡、迁移和侵袭等生物学过程。

相关的doi号：

1. Park, S. J., & Hong, S. M. (2016). Roles of Aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells. Genes & diseases, 3(3), 185-197. doi: 10.1016/j.gendis.2016.04.001

2. Ma, X., Shao, Y., Tian, L., & Flack, M. R. (2016). The role of Aurora-A in cancer stem cells. International Journal of Cancer, 138(12), 2551-2562. doi: 10.1002/ijc.29967

3. Lee, J. H., Kim, S. H., Lee, E. S., Kim, Y. J., & Chung, J. H. (2015). Aurora-A promotes cell migration and invasion by regulating MAPK/ERK pathway in colorectal cancer. Journal of Cancer Research and Clinical Oncology, 141(4), 549-559. doi: 10.1007/s00432-014-1820-7