灵菌红素对感染金黄色葡萄球菌小鼠肠道菌群的调节作用 论文

摘要：

本研究探讨了灵菌红素（aspergillic acid）对感染金黄色葡萄球菌（Staphylococcus aureus）小鼠肠道菌群的调节作用。采用小鼠模型，将小鼠随机分为对照组、感染组和治疗组，感染组和治疗组皆接种金黄色葡萄球菌，治疗组在感染后给予灵菌红素治疗。实验结果表明，感染组小鼠肠道菌群多样性和丰富度均显著下降，与对照组相比，肠道菌群的差异指数（beta diversity）显著增加。而灵菌红素治疗组肠道菌群多样性和丰富度显著增加，与感染组相比，肠道菌群的差异指数显著降低。同时，灵菌红素治疗组的丙酸菌门（Firmicutes）和拟杆菌门（Bacteroidetes）比例较感染组有所恢复，且肠道中炎性因子的表达水平显著下降。因此，灵菌红素具有对感染金黄色葡萄球菌小鼠肠道菌群的调节作用，并可促进肠道菌群的恢复和降低肠道炎症反应。

关键词：灵菌红素；金黄色葡萄球菌；肠道菌群；多样性；丰富度；炎性因子

Regulatory effect of aspergillic acid on gut microbiota in Staphylococcus aureus-infected mice

Abstract:

This study investigated the regulatory effect of aspergillic acid on gut microbiota in Staphylococcus aureus-infected mice. Mice were randomly divided into control group, infection group, and treatment group. The infection group and treatment group were both inoculated with Staphylococcus aureus, and the treatment group was given aspergillic acid after infection. The results showed that the diversity and richness of gut microbiota in the infection group were significantly decreased, and the beta diversity index was significantly increased compared with the control group. However, the diversity and richness of gut microbiota in the aspergillic acid treatment group were significantly increased, and the beta diversity index was significantly decreased compared with the infection group. Moreover, the ratio of Firmicutes and Bacteroidetes in the gut of the aspergillic acid treatment group was restored compared with the infection group, and the expression levels of inflammatory factors in the gut were significantly decreased. Therefore, aspergillic acid has a regulatory effect on gut microbiota in Staphylococcus aureus-infected mice, and can promote the recovery of gut microbiota and reduce gut inflammation.

Keywords: aspergillic acid; Staphylococcus aureus; gut microbiota; diversity; richness; inflammatory factors