Artificial Stimulation of TRPM8 Neurons: How it Creates the Sensation of Coldness

Artificial electrical stimulation of a human's TRPM8-containing neurons would likely produce the sensation of coldness or coolness. TRPM8 is a thermosensitive ion channel that is primarily activated by cold temperatures. When these neurons are artificially stimulated, they send signals to the brain that are typically interpreted as cold sensations. This is why artificial stimulation of TRPM8-containing neurons can be used to create the feeling of coldness in various applications, such as in medical treatments or virtual reality simulations.