Nucleus export signal

A nucleus export signal (NES) is a short amino acid sequence found in proteins that directs their movement out of the cell nucleus and into the cytoplasm. This signal is recognized by a protein called exportin, which binds to the NES and facilitates the transport of the protein through nuclear pores. NESs are typically rich in hydrophobic amino acids and are often located in the disordered regions of proteins. They are important for regulating the subcellular localization of many proteins, including transcription factors, RNA-binding proteins, and signaling molecules. Dysregulation of NES-mediated protein transport has been implicated in a number of diseases, including cancer and neurodegenerative disorders.