蛋白质互作的生物信息学技术主要包括蛋白质互作预测、蛋白质复合物分析、蛋白质互作网络分析等。常用的工具和软件包括STRING、BioGRID、APID、HPRD、InWeb_IM、Cytoscape等。

参考文献:

  1. Szklarczyk D, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47(D1):D607-D613.

  2. Chatr-aryamontri A, et al. The BioGRID interaction database: 2017 update. Nucleic Acids Res. 2017;45(D1):D369-D379.

  3. Alcázar R, et al. APID interactomes: providing proteome-based interactomes with controlled quality for multiple species and derived networks. Nucleic Acids Res. 2011;39(Web Server issue):W687-W691.

  4. Peri S, et al. Human protein reference database as a discovery resource for proteomics. Nucleic Acids Res. 2004;32(Database issue):D497-D501.

  5. Li T, et al. InWeb_IM: an integrated network-based approach to interpret multi-omics data for human diseases. BMC Genomics. 2018;19(Suppl 7):492.

  6. Shannon P, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498-2504.

蛋白质互作的生物信息学技术上有哪些?并列出参考文献?

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