润色以下论文语句：TNF-a first appears during the inflammatory response in biological organisms It stimulates the acute phase reaction of cell factors and responds to stimuli such as infection or tissue damage

TNF-a is initially detected during the inflammatory response in biological organisms. It plays a crucial role in stimulating the acute phase reaction of cell factors and responds to stimuli like infection or tissue damage. It circulates in the systemic circulation of the organism, activating neutrophils and lymphocytes, modifying the characteristics of vascular endothelial cells, regulating metabolic activity in other tissues, and displaying cytotoxic activity by inducing local coagulation.