润色以下论文语句：TNF-a is first appeared in the process of biological organism inflammatory response It can stimulates the acute phase reaction effect of cell factor it can with the stimulus response infecti

TNF-a first appears during the inflammatory response in biological organisms. It stimulates the acute phase reaction of cell factors and responds to stimuli such as infection or tissue damage. It circulates in the systemic circulation of the organism, activating neutrophils and lymphocytes, altering the characteristics of vascular endothelial cells, regulating metabolic activity in other tissues, and exhibiting cytotoxic activity by inducing local coagulation.