我们将启动子活性与其甲基化状态呈现负相关的189个选择性启动子定义为甲基化调控的选择性启动子methylation-regulated APmrAP。mrAPs的活性变化与其甲基化水平改变呈现明显的负相关R = -076p-value = 12e-13图3-18 A。对具有mrAPs的基因进行功能富集分析结果显示其在MAPK级联激活、囊泡介导的运输调节、Ras蛋白信号转导等细胞信号转导通路以及细胞

Translation: We defined 189 selective promoters that show a negative correlation between their activity and methylation status as methylation-regulated APs (mrAPs). The activity changes of mrAPs are significantly negatively correlated with their methylation levels (R = -0.76, p-value = 1.2e-13) (Figure 3-18 A). Functional enrichment analysis of genes with mrAPs revealed significant enrichment in cell signaling pathways such as MAPK cascade activation, vesicle-mediated transport regulation, Ras protein signal transduction, as well as tumor-related pathways including negative regulation of cell cycle, cell proliferation, and cell growth regulation (Figure 3-18 B). These findings suggest that these genes play important roles in multiple cell signaling pathways and may be closely associated with tumor initiation and progression.