Epigenetics plays a crucial role in the regulation of cellular differentiation and development. However, traditional techniques for analyzing the epigenome require a large number of cells. In recent years, high-throughput sequencing methods have rapidly advanced. One such technique is the assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq), which can identify open chromatin regions and regulatory sequences in the genome with as few as 500 cells. This article provides a comprehensive review of the advantages of ATAC-seq technology and its applications and prospects in human developmental research. The aim is to provide guidance and reference for studies related to human cells and embryonic development

将以下文字翻译成学术英语:表观遗传学对于研究细胞分化、发育的调控过程有着至关重要的作用。然而应用传统的技术手段去分析表观基因组需要提供大量充足的细胞。近年来高通量测序法快速发展其中典型的有assay for transposase-accessible chromatin with high-throughput sequencing即ATAC-seq技术该技术最少仅需约500个细胞就可以得到染色

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