请改写下列句子表达避免出现与原文连续4个单词重复：Alzheimer’s disease AD is characterized by the accumulation of intracellular accumulation of insoluble hyperphosphorylated tau proteins p-tau and abnormal protein deposits or

AD is distinguished by the buildup of intracellular insoluble p-tau proteins and abnormal protein deposits called plaques, which consist of Ab peptides (Ab1–40 and Ab1–42).