Use a betteer expression to translate this sentencesCapon23发现LamO是一种有效且选择性的BCRP抑制剂。BCRP是一种ATP结合ABC转运体它可以增加临床化疗药物的外排导致癌症细胞的多药耐药MDR。作者先用阿霉素耐药逆转试验证明LamO可以逆转P-gp过表达的癌细胞耐药性。同时作者证明LamO可以提高BCRP过表达的癌细胞3H-米托蒽醌

Capon[23] discovered that LamO is an effective and selective inhibitor of BCRP. BCRP is an ATP-binding cassette (ABC) transporter that can increase the efflux of clinical chemotherapeutic drugs, leading to multidrug resistance (MDR) in cancer cells. The author demonstrated the ability of LamO to reverse P-gp overexpression-mediated drug resistance in cancer cells using a doxorubicin-resistant reversal assay. Additionally, the author proved that LamO can increase the accumulation of [3H]-mitoxantrone drug in cancer cells overexpressing BCRP, indicating the ability of LamO to inhibit the efflux function of BCRP. The key functional groups responsible for inhibition were identified through docking studies as methoxyphenyl ketone, carboxylic acid ester, and phenolic residue.