改写Malignancy and immune infiltration are associated with DNA damage assessment including aneuploidy homologous recombination deficiency HRD fraction of altered and number of segments Aneuploidy is ubi

DNA damage assessment, including aneuploidy, homologous recombination deficiency (HRD), fraction of altered and number of segments, is associated with malignancy and immune infiltration. Aneuploidy, which is commonly observed in various cancers, indicates a higher degree of immune evasion and lower response to immunotherapy [16]. The aneuploidy scores of C3 were significantly higher compared to C1 and C2 (Figure 4A). Furthermore, patients in C3 had a higher incidence of HRD compared to those in C1 and C2 (Figure 4B). Previous studies have reported that apoptosis-resistant tumors are associated with a higher degree of HRDs and fraction altered, but not with mutation rates. Similarly, patients in C1 and C2 had a lower fraction altered than those in the stemness subtype C3 (Figure 4C). Patients in C1 had a lower number of segments compared to those in the stemness subtype C3 (Figure 4D). Additionally, there was a statistically significant difference in the nonsilent mutation rate between the stemness subtype C3 and C1 (Figure 4E).