Here we report that thekey T helper 17 TH17 cell diferentiation stimulator STAT334 is subject to reversibleS-palmitoylation on cysteine 108 DHHC7 palmitoylates STAT3 and promotes itsmembrane recruitme

In summary, this study highlights the importance of S-palmitoylation in regulating the activation and differentiation of TH17 cells through the modulation of STAT3. The reversible nature of this modification allows for tight control of the signalling pathway and provides a potential therapeutic target for diseases associated with TH17 cell overactivation, such as IBD. Additionally, this research sheds light on the broader role of S-palmitoylation in regulating cellular signalling pathways and opens up new avenues for understanding and manipulating these processes.